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Masaaki Tokuda Selected Research

psicose (D-psicose)

6/2022Not only metformin, but also D-allulose, alleviates metabolic disturbance and cognitive decline in prediabetic rats.
1/2022Insulin mimetic effect of D-allulose on apolipoprotein A-I gene.
6/2021D-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats.
1/2018GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose.
11/2017The long-term safety of D-allulose administration in healthy dogs.
12/2016Effects of D-allulose on glucose metabolism after the administration of sugar or food in healthy dogs.
7/2016Single oral dose safety of D-allulose in dogs.
11/2015Rare sugar D-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus.
7/2015Beneficial Effects of Supplementation of the Rare Sugar "D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice.
1/2015Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats.
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Masaaki Tokuda Research Topics

Disease

22Neoplasms (Cancer)
11/2018 - 01/2002
11Body Weight (Weight, Body)
06/2021 - 02/2010
9Ischemia
09/2016 - 09/2002
9Reperfusion Injury
09/2016 - 01/2003
8Insulin Resistance
01/2022 - 02/2011
8Hepatocellular Carcinoma (Hepatoma)
01/2022 - 03/2005
7Obesity
06/2021 - 07/2014
7Carcinoma (Carcinomatosis)
12/2014 - 08/2002
6Hyperglycemia
01/2018 - 09/2012
4Glucose Intolerance
01/2018 - 11/2015
4Hypoxia (Hypoxemia)
01/2017 - 05/2015
4Inflammation (Inflammations)
09/2016 - 11/2012
4Type 2 Diabetes Mellitus (MODY)
11/2015 - 02/2011
4Squamous Cell Carcinoma of Head and Neck
08/2009 - 01/2002
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2018 - 07/2002
3Adenocarcinoma
03/2018 - 12/2014
3Brain Ischemia (Cerebral Ischemia)
09/2016 - 11/2004
3Atrophy
01/2011 - 08/2002
2Mitochondrial Diseases (Mitochondrial Disease)
06/2022 - 06/2021
2Diabetes Mellitus
01/2021 - 07/2007
2Head and Neck Neoplasms (Head and Neck Cancer)
03/2018 - 11/2014
2Fibrosis (Cirrhosis)
01/2017 - 09/2012
2Hypertension (High Blood Pressure)
11/2015 - 10/2005
2Atherosclerosis
11/2015 - 07/2007
2Hyperlipidemias (Hyperlipidemia)
07/2015 - 01/2014
2Glioma (Gliomas)
10/2013 - 01/2013
2Chronic Hepatitis (Chronic Active Hepatitis)
12/2008 - 03/2005
2Ovarian Neoplasms (Ovarian Cancer)
10/2007 - 07/2005
2Ovarian Epithelial Carcinoma
04/2006 - 08/2002
2Lymphatic Metastasis
07/2002 - 01/2002
1Cognitive Dysfunction
06/2022
1Chronic Disease (Chronic Diseases)
02/2022
1Cardiovascular Diseases (Cardiovascular Disease)
06/2021
1Dental Caries (Decay, Dental)
08/2020
1Periodontitis
08/2020
1Allergic Rhinitis
08/2019
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2018
1Lung Neoplasms (Lung Cancer)
03/2018
1Abdominal Obesity
01/2018
1Hyperphagia (Overeating)
01/2018
1Weight Loss (Weight Reduction)
04/2017
1Brain Injuries (Brain Injury)
09/2016
1Diarrhea
07/2016
1Vomiting
07/2016
1Neurodevelopmental Disorders
01/2016
1Breast Neoplasms (Breast Cancer)
01/2016

Drug/Important Bio-Agent (IBA)

22SugarsIBA
01/2021 - 01/2004
20psicose (D-psicose)IBA
06/2022 - 07/2005
20alloseIBA
03/2018 - 01/2003
14Proteins (Proteins, Gene)FDA Link
11/2018 - 01/2002
9Glucose (Dextrose)FDA LinkGeneric
01/2016 - 10/2005
6Insulin (Novolin)FDA Link
06/2022 - 02/2011
6ThioredoxinsIBA
11/2018 - 02/2008
4Messenger RNA (mRNA)IBA
03/2018 - 12/2008
4Glutamic Acid (Glutamate)FDA Link
10/2014 - 04/2006
4Neuroprotective AgentsIBA
10/2014 - 03/2004
3Metformin (Glucophage)FDA LinkGeneric
06/2022 - 11/2015
3MonosaccharidesIBA
04/2017 - 02/2008
3Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2016 - 04/2006
3Blood Glucose (Blood Sugar)IBA
01/2015 - 02/2011
3SurvivinIBA
04/2006 - 07/2002
2Sweetening Agents (Sweeteners)IBA
01/2022 - 04/2017
2Dizocilpine Maleate (Dizocilpine)IBA
01/2022 - 10/2013
2tagatose (D-tagatose)IBA
01/2022 - 08/2020
2Excitatory Amino Acid AntagonistsIBA
01/2022 - 10/2013
2Therapeutic UsesIBA
06/2021 - 08/2019
2LipidsIBA
06/2021 - 01/2018
2Docetaxel (Taxotere)FDA Link
03/2018 - 11/2014
2Cisplatin (Platino)FDA LinkGeneric
03/2018 - 11/2012
2CytokinesIBA
09/2016 - 02/2006
2Transcription Factors (Transcription Factor)IBA
03/2016 - 01/2005
2Indicators and Reagents (Reagents)IBA
01/2016 - 01/2005
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2015 - 11/2004
2Polyethylene (Polythene)IBA
01/2014 - 01/2004
2FructoseIBA
01/2014 - 08/2009
2Hematoxylin (Haematoxylon)IBA
08/2013 - 09/2012
2Oxygen (Dioxygen)IBA
09/2008 - 04/2006
2Retinaldehyde (Retinal)IBA
09/2008 - 04/2006
2Diethylhexyl Phthalate (DEHP)IBA
09/2007 - 08/2002
2S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA
04/2006 - 03/2003
2Glutathione (Reduced Glutathione)IBA
11/2005 - 08/2002
1COVID-19 VaccinesIBA
02/2022
1CholesterolIBA
06/2021
1oxidized low density lipoproteinIBA
06/2021
1Anti-Allergic Agents (Antiallergic Agents)IBA
08/2019
1Hexosaminidases (Hexosaminidase)IBA
08/2019
1Glucagon-Like Peptide 1 (GLP 1)IBA
01/2018
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2017
1CateninsIBA
01/2017
1Dactinomycin (Actinomycin)FDA LinkGeneric
01/2017
11-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)IBA
01/2017
1Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
01/2017
1Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA
01/2017
1isoamericanol AIBA
01/2016
1ArsenicIBA
01/2016
1Calcium-Binding ProteinsIBA
01/2016
1LuciferasesIBA
01/2016
1S100 Proteins (S 100 Protein)IBA
01/2016

Therapy/Procedure

2Therapeutics
11/2018 - 09/2008
2Oral Administration
01/2014 - 08/2002